![]() At 36 months, 24 h SBP was controlled to <130 mmHg in 40% of RDN patients in the morning compared to 6% for the sham group P = 0.021 and in 80% of the RDN patients at night compared to 39% in the sham group P = 0.019. In patients taking at least 3 antihypertensive medications at 36 months ( N = 23 RDN group N = 23 sham group), the 24 h ambulatory SBP as well as morning (7:00–9:00AM) and nighttime (1:00–6:00AM) ambulatory SBP were significantly lower for the RDN group compared to sham control (24 h SBP: −20.2 vs. Eighty patients were randomized to RDN or sham control. We compared the long-term changes in morning and nighttime BP in patients with uncontrolled hypertension (office systolic BP between 150 and <180 mmHg/diastolic BP ≥ 90 mmHg mean ambulatory systolic BP (SBP) between 140 and <170 mmHg 1–3 prescribed antihypertensive medications). Elevated morning and nighttime blood pressures (BP) are associated with increased risk of cardiovascular events such as stroke and myocardial infarction.
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